Thus the entry 4 of Table 1 was selected and the reactions were continued under optimized conditions. The product was obtained using 10 mol% of FeP 4 in 92% yield. The conversion was completed at appreciated time in table 1. In a model reaction, with benzaldehyde (5.0 mmol), acetophenone (5.0 mmol), AcCl (1.5 mmol), acetonitrile (1.0 ml) and FeP 4 (0, 2, 5, 10, 15 mol %) stirred at room temperature without solvent. bviously, the catalyst is an effective component for this reaction. The reaction was not completed even after 24 h. Results and discussion At the first, the reaction of benzaldehyde, acetophenone, acetyl chloride and acetonitrile was studied in the absence of catalyst. 14 In this communication we wish to report synthesis of β-amido ketones with enolizable ketones, acetonitrile, benzonitrile and acetyl chloride in the presence of FeP 4 at room temperature (Scheme 1). In addition to mentioned above, FeP 4 is cheap, safe and available reagent 8 that has also been employed for the selective oxidation of C 4 to C 3 9 and benzene to phenol 10 one-pot synthesis of dihydropyrimidinones and thiones 11, one-pot three component synthesis of 2,4,5- trisubstituted imidazoles 12, acetylation alcohols and phenols 13 and tetrahydropyranylation alcohols and phenols. Recently, Fe(Cl 4) 3 6 and CuS was also reported by our research group. 4 Another procedure for the formation of these compounds from condensation of enolizable ketones, an aryl aldehyde, and acetyl chloride in nitriles in the presence of heterogeneous and homogeneous acid catalysts have been reported by abid and Tabatabaei 5 and others references therein. The best-known route for the synthesis of these compounds is the Dakin West reaction, 3 which involves the condensation of an α- amino acid with acetic anhydride in the presence of a base to afford the β-acetamido ketones. Introduction β-acetamido ketone skeletons exist in a number of biological and pharmaceutical compounds makes them valuable building blocks 1,2 and there have been intensive attempts to synthesize β-amido ketones. Department of Chemistry, Shahr-E-Rey Branch, Islamic Azad University, Tehran, Iran. Corresponding Authors Tel: Fax: Department of chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran. The use of readily available FeP4 as a catalyst renders this process quite simple and convenient. Three new compounds and rare β-amido ketones are reported additionally. Behbahani *, Sara aeini, Saeed Suzangarzadeh Keywords: iron(iii) phosphate (FeP4) β-acetamido carbonyl compounds catalyst synthesis Aldehydes have been used in a one-pot reaction with enolizable ketones, acetonitrile, benzonitrile and acetyl chloride in the presence of FeP4 at room temperature to form the corresponding β-acetamido ketones in very good yields. "Yakety Sax" (From The "Essential Chet Atkins" Version) Tabbed By: TheLoser (17 Years Old ) e-mail me with any suggestions, though I'm sure this is 100% right, except for that one chord name.
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